This platform leverages DNA-Encoded Library (DEL) technology, where small molecules are covalently linked to unique DNA barcodes, enabling traceable and efficient screening. With a library capacity of hundreds of millions of compounds, the platform performs ultra-high-throughput screening with minimal sample consumption. By combining affinity-based selection with next-generation sequencing and advanced data analysis, it rapidly identifies potential active compounds. DEL technology significantly accelerates early drug discovery and is applicable to various target types, including enzymes, receptors, and protein–protein interactions.