We have developed and validated multiple DNA-compatible chemical reaction systems that cover the formation of key chemical bonds, such as C–C and C–X (halogen), as well as the efficient construction of diverse structures, including advantageous skeletons like aromatic heterocycles, saturated heterocycles, and spiro rings, and cyclic peptides. Regarding building block resources, AlphaMa possesses a rich and scalable synthetic building block library, including amines, carboxylic acids, boronic acids, aldehydes, and other monofunctional building blocks; amino acids, acid-aldehydes, diamines, and other bifunctional building blocks; and trifunctional reagents, such as carboxylic acid-aldehyde-halide trifunctional reagents and acid-amine-halides. Specialized building blocks can be customized to meet specific project requirements as well. Leveraging our mature chemical R&D capabilities and years of library construction experience, we can redesign synthetic routes for projects. This approach significantly enhances structural diversity and chemical space coverage while ensuring the physicochemical properties and nucleic acid compatibility. It also improves the purity of the delivered compound libraries, thereby boosting screening efficiency and hit rates.